PPT1
Gene Ontology Biological Process
- brain development [IMP]
- cofactor metabolic process [IMP]
- cofactor transport [IMP]
- lipid catabolic process [IDA]
- lysosomal lumen acidification [IMP]
- membrane raft organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nervous system development [IMP]
- neuron development [TAS]
- pinocytosis [IMP]
- positive regulation of pinocytosis [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- protein catabolic process [NAS]
- protein depalmitoylation [IDA, ISS]
- protein transport [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of synapse structure or activity [NAS]
- sphingolipid catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells.
Neuronal ceroid lipofuscinoses (NCL) are a group of inherited progressive childhood disorders, characterized by early accumulation of autofluorescent storage material in lysosomes of neurons or other cells. Clinical symptoms of NCL include: progressive loss of vision, mental and motor deterioration, epileptic seizures and premature death. CLN1 disease (MIM#256730) is caused by mutations in the CLN1 gene, which encodes palmitoyl protein ... [more]
Throughput
- High Throughput
Additional Notes
- SAINT analysis: Proteins with AvgP >= 0.5 in at least two out of three biological replicates were accepted.
- Single affinity purification in SH-SY5Y cells
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPT1 MAP1B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID