PSMD14
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PSMC5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- blood microparticle [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [ISO]
- cytosolic proteasome complex [ISO]
- extracellular vesicular exosome [ISO]
- holo TFIIH complex [ISA]
- inclusion body [ISO]
- membrane [ISO]
- nuclear proteasome complex [ISO]
- nucleus [ISO]
- proteasome accessory complex [IDA]
- proteasome complex [ISO]
- proteasome regulatory particle [IDA]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death.
Proteasome-mediated proteolysis is a major protein degradation mechanism in cells and its dysfunction has been implicated in the pathogenesis of several neurodegenerative diseases, each with the common features of neuronal death and formation of ubiquitinated inclusions found within neurites, the cell body, or nucleus. Previous models of proteasome dysfunction have employed pharmacological inhibition of the catalytic subunits of the 20S ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PSMD14 PSMC5 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.968 | BioGRID | 2673088 |
Curated By
- BioGRID