PLCG1
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- in utero embryonic development [IMP]
- inositol trisphosphate biosynthetic process [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein secretion [ISO]
- regulation of store-operated calcium channel activity [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NTRK1
Gene Ontology Biological Process
- B cell differentiation [IMP]
- Sertoli cell development [ISO]
- axon guidance [ISO]
- axonogenesis involved in innervation [IMP]
- cellular response to growth factor stimulus [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- cellular response to nicotine [ISO]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- detection of temperature stimulus involved in sensory perception of pain [ISO]
- developmental programmed cell death [ISO]
- learning or memory [ISO]
- mechanoreceptor differentiation [IMP]
- negative regulation of neuron apoptotic process [IGI, IMP, ISO]
- negative regulation of neuron death [ISO]
- nerve growth factor signaling pathway [IGI, ISO]
- nervous system development [IDA]
- neurotrophin TRK receptor signaling pathway [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of programmed cell death [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to activity [ISO]
- response to drug [ISO]
- response to electrical stimulus [ISO]
- response to nicotine [ISO]
- response to nutrient levels [ISO]
- sensory perception of pain [ISO]
- sympathetic nervous system development [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [ISO]
- kinase binding [ISO]
- nerve growth factor binding [ISO]
- nerve growth factor receptor activity [ISO]
- neurotrophin p75 receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- ephrin receptor binding [ISO]
- kinase binding [ISO]
- nerve growth factor binding [ISO]
- nerve growth factor receptor activity [ISO]
- neurotrophin p75 receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Lysosomal accumulation of Trk protein in brain of GMâ‚ -gangliosidosis mouse and its restoration by chemical chaperone.
G(M1) -gangliosidosis is a fatal neurodegenerative disorder caused by deficiency of lysosomal acid β-galactosidase (β-gal). Accumulation of its substrate ganglioside G(M1) (G(M1) ) in lysosomes and other parts of the cell leads to progressive neurodegeneration, but underlying mechanisms remain unclear. Previous studies demonstrated an essential role for interaction of G(M1) with tropomyosin receptor kinase (Trk) receptors in neuronal growth, survival ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID