Muscle contractile proteins are expressed as a series of developmental isoforms that are in constant dynamic remodeling during embryogenesis, but how obsolete molecules are recognized and removed is not known. Ozz is a developmentally regulated protein that functions as the adaptor component of a RING-type ubiquitin ligase complex specific to striated muscle. Ozz(-/-) mutants exhibit defects in myofibrillogenesis and myofiber ... [more]

PLoS ONE Mar. 31, 2010; 5(3);e9866 [Pubmed: 20352047]

Throughput

Low Throughput

Additional Notes

E2: UbcH5b

Curated By

BioGRID

Interaction Summary

RBX1

Gene Ontology Biological Process

Gene Ontology Molecular Function

cullin family protein binding [ISO]eukaryotic initiation factor 4E binding [TAS]protein binding [IPI]protein complex binding [ISO]ubiquitin protein ligase activity [ISO]ubiquitin-protein transferase activity [TAS]ubiquitin-ubiquitin ligase activity [ISO]

Gene Ontology Cellular Component

UBE2D2A

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]ubiquitin conjugating enzyme activity [ISO]ubiquitin-protein transferase activity [ISO]

Gene Ontology Cellular Component

Reconstituted Complex

Publication

Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development.

Throughput

Additional Notes

Curated By

cullin family protein binding [ISO]
eukaryotic initiation factor 4E binding [TAS]
protein binding [IPI]
protein complex binding [ISO]
ubiquitin protein ligase activity [ISO]
ubiquitin-protein transferase activity [TAS]
ubiquitin-ubiquitin ligase activity [ISO]

protein binding [IPI]
ubiquitin conjugating enzyme activity [ISO]
ubiquitin-protein transferase activity [ISO]