BAIT
MIB1
mindbomb E3 ubiquitin protein ligase 1
GO Process (11)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- Notch signaling pathway [IBA, ISO]
- blood vessel development [ISO]
- endocytosis [IBA]
- heart development [ISO]
- heart looping [ISO]
- in utero embryonic development [ISO]
- negative regulation of neuron differentiation [ISO]
- neural tube formation [ISO]
- positive regulation of endocytosis [ISO]
- protein ubiquitination [IBA]
- somitogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PARVA
Actp
parvin, alpha
GO Process (11)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- actin cytoskeleton organization [IDA]
- actin-mediated cell contraction [ISO, ISS]
- cell adhesion [ISO]
- cilium morphogenesis [ISO, ISS]
- establishment or maintenance of cell polarity [ISO, ISS]
- heterotypic cell-cell adhesion [ISO, ISS]
- outflow tract septum morphogenesis [ISO, ISS]
- protein heterooligomerization [IDA, IPI]
- smooth muscle cell chemotaxis [ISO, ISS]
- sprouting angiogenesis [ISO, ISS]
- substrate adhesion-dependent cell spreading [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Sequential elution interactome analysis of the Mind bomb 1 ubiquitin ligase reveals a novel role in dendritic spine outgrowth.
The mind bomb 1 (Mib1) ubiquitin ligase is essential for controlling metazoan development by Notch signaling and possibly the Wnt pathway. It is also expressed in postmitotic neurons, regulating neuronal morphogenesis and synaptic activity, but by mechanisms that are largely unknown. We sought to comprehensively characterize the Mib1 interactome and study its potential function in neuron development utilizing a novel ... [more]
Mol. Cell Proteomics Apr. 30, 2015; 0(0); [Pubmed: 25931508]
Throughput
- High Throughput
Curated By
- BioGRID