BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HDAC6
Hd6, Hdac5, Sfc6, mHDA2, RP23-198C2.1
histone deacetylase 6
GO Process (34)
GO Function (15)
GO Component (19)
Gene Ontology Biological Process
- Hsp90 deacetylation [IMP, ISO]
- aggresome assembly [IGI, ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to misfolded protein [IMP]
- cellular response to topologically incorrect protein [ISO]
- histone deacetylation [IDA, ISO]
- intracellular protein transport [ISO]
- lysosome localization [ISO]
- macroautophagy [ISO]
- misfolded or incompletely synthesized protein catabolic process [ISO]
- negative regulation of microtubule depolymerization [IDA]
- negative regulation of protein complex disassembly [ISO]
- negative regulation of proteolysis [ISO]
- peptidyl-lysine deacetylation [ISO]
- polyubiquitinated misfolded protein transport [ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of hydrogen peroxide-mediated programmed cell death [ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of signal transduction [ISO]
- protein complex disassembly [IGI]
- protein deacetylation [IDA, ISO]
- protein polyubiquitination [IDA]
- regulation of establishment of protein localization [IMP]
- regulation of fat cell differentiation [IMP]
- regulation of gene expression, epigenetic [ISO]
- regulation of receptor activity [ISO]
- response to growth factor [ISO]
- response to misfolded protein [ISO]
- response to organic substance [ISO]
- response to toxic substance [ISO]
- tubulin deacetylation [IDA, IMP, ISO]
- ubiquitin-dependent protein catabolic process [IGI, IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- alpha-tubulin binding [ISO]
- beta-catenin binding [ISO]
- beta-tubulin binding [IDA]
- core promoter binding [ISO]
- dynein complex binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- microtubule binding [IDA, ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
- tubulin deacetylase activity [IDA, ISO]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [ISO]
- Hsp90 protein binding [ISO]
- alpha-tubulin binding [ISO]
- beta-catenin binding [ISO]
- beta-tubulin binding [IDA]
- core promoter binding [ISO]
- dynein complex binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- microtubule binding [IDA, ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
- tubulin deacetylase activity [IDA, ISO]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- aggresome [ISO]
- axon [IDA, ISO]
- caveola [ISO]
- cell leading edge [ISO]
- centrosome [ISO]
- cytoplasm [IDA]
- cytoplasmic microtubule [IDA]
- cytosol [IDA]
- dendrite [IDA]
- dynein complex [ISO]
- histone deacetylase complex [ISO]
- inclusion body [ISO]
- microtubule [ISO]
- microtubule associated complex [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, TAS]
- perikaryon [IDA]
- perinuclear region of cytoplasm [ISO]
- protein complex [IPI]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
HDAC6-p97/VCP controlled polyubiquitin chain turnover.
HDAC6 is a unique cytoplasmic deacetylase capable of interacting with ubiquitin. Using a combination of biophysical, biochemical and biological approaches, we have characterized the ubiquitin-binding domain of HDAC6, named ZnF-UBP, and investigated its biological functions. These studies show that the three Zn ion-containing HDAC6 ZnF-UBP domain presents the highest known affinity for ubiquitin monomers and mediates the ability of HDAC6 ... [more]
EMBO J. Jul. 26, 2006; 25(14);3357-66 [Pubmed: 16810319]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Figure 2
- Likely protein-protein interaction
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC6 UBC | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 797020 | |
| UBC HDAC6 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | 2297414 |
Curated By
- BioGRID