BIRC3
Gene Ontology Biological Process
- cytokinesis [IBA]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- necroptotic process [IDA]
- negative regulation of apoptotic process [IBA]
- negative regulation of necroptotic process [IMP]
- negative regulation of phosphorylation [IMP]
- negative regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of protein ubiquitination [ISO]
- protein heterooligomerization [ISO]
- protein ubiquitination [IBA, ISO]
- regulation of apoptotic process [ISO]
- regulation of necroptotic process [ISO]
- regulation of toll-like receptor signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IBA, ISO]
- membrane raft [ISO]
- nucleoplasm [ISO]
- nucleus [IBA, ISO]
- protein complex [ISO]
CASP9
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic process [IDA, ISO]
- cellular response to DNA damage stimulus [IMP, ISO]
- cellular response to UV [ISO]
- cellular response to dexamethasone stimulus [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [IGI, IMP]
- proteolysis [IDA, ISO]
- regulation of response to DNA damage stimulus [ISO]
- response to UV [IMP]
- response to organic cyclic compound [ISO]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apoptosome [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- intracellular [IBA]
- mitochondrion [ISO]
- nucleus [IDA, ISO]
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.
Omi/HtrA2 is a mitochondrial serine protease that is released into the cytosol during apoptosis to antagonize inhibitors of apoptosis (IAPs) and contribute to caspase-independent cell death. Here, we demonstrate that Omi/HtrA2 directly cleaves various IAPs in vitro, and the cleavage efficiency is determined by its IAP-binding motif, AVPS. Cleavage of IAPs such as c-IAP1 substantially reduces its ability to inhibit ... [more]
Throughput
- Low Throughput
Additional Notes
- in the presence of E1 and UbcH6
Curated By
- BioGRID