BIRC3
Gene Ontology Biological Process
- cytokinesis [IBA]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- necroptotic process [IDA]
- negative regulation of apoptotic process [IBA]
- negative regulation of necroptotic process [IMP]
- negative regulation of phosphorylation [IMP]
- negative regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of protein ubiquitination [ISO]
- protein heterooligomerization [ISO]
- protein ubiquitination [IBA, ISO]
- regulation of apoptotic process [ISO]
- regulation of necroptotic process [ISO]
- regulation of toll-like receptor signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IBA, ISO]
- membrane raft [ISO]
- nucleoplasm [ISO]
- nucleus [IBA, ISO]
- protein complex [ISO]
CASP3
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- T cell homeostasis [IMP]
- apoptotic process [IDA, ISO]
- cell fate commitment [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to organic substance [IDA]
- erythrocyte differentiation [IBA, ISO]
- execution phase of apoptosis [IDA, IGI, IMP, ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- glial cell apoptotic process [IMP]
- heart development [IGI]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]
- keratinocyte differentiation [IMP]
- learning or memory [ISO]
- negative regulation of B cell proliferation [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- neuron apoptotic process [IDA, IGI, IMP]
- neuron differentiation [IBA]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of neuron apoptotic process [IDA, ISO]
- protein processing [IDA]
- proteolysis [IMP, ISO]
- regulation of apoptotic DNA fragmentation [IMP]
- release of cytochrome c from mitochondria [IGI]
- response to UV [IDA, IGI]
- response to glucose [ISO]
- response to hydrogen peroxide [ISO]
- response to wounding [IDA]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function- aspartic-type endopeptidase activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IMP]
- cysteine-type endopeptidase activity [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA, ISO]
- cysteine-type peptidase activity [IDA, ISO]
- death receptor binding [ISO]
- peptidase activity [IDA, IMP, ISO]
- phospholipase A2 activator activity [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- aspartic-type endopeptidase activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IMP]
- cysteine-type endopeptidase activity [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA, ISO]
- cysteine-type peptidase activity [IDA, ISO]
- death receptor binding [ISO]
- peptidase activity [IDA, IMP, ISO]
- phospholipase A2 activator activity [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.
Omi/HtrA2 is a mitochondrial serine protease that is released into the cytosol during apoptosis to antagonize inhibitors of apoptosis (IAPs) and contribute to caspase-independent cell death. Here, we demonstrate that Omi/HtrA2 directly cleaves various IAPs in vitro, and the cleavage efficiency is determined by its IAP-binding motif, AVPS. Cleavage of IAPs such as c-IAP1 substantially reduces its ability to inhibit ... [more]
Throughput
- Low Throughput
Additional Notes
- in the presence of E1 and UbcH6
Curated By
- BioGRID