SUMO1
Gene Ontology Biological Process
- PML body organization [IMP]
- negative regulation of DNA binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- palate development [IMP]
- positive regulation of calcium-transporting ATPase activity [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein localization to nuclear pore [IMP]
- protein sumoylation [IDA, IMP, ISO]
- regulation of calcium ion transmembrane transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of protein stability [IMP]
- regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
VHL
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IMP]
- angiogenesis [IMP]
- blood vessel endothelial cell migration [IMP]
- extracellular matrix organization [IMP]
- negative regulation of thymocyte apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- neuron differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- proteasomal protein catabolic process [IMP]
- protein catabolic process [IMP]
- protein heterooligomerization [ISO]
- protein transport [IDA]
- protein ubiquitination [ISO]
- regulation of apoptotic signaling pathway [IGI]
- regulation of catecholamine metabolic process [ISO]
- regulation of thymocyte apoptotic process [IGI]
- regulation of transcription, DNA-templated [ISO]
- response to hypoxia [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases (SENPs). The physiologic consequences of SUMOylation and deSUMOylation are not fully understood. Here we investigate the phenotypes of mice lacking SENP1 and find that SENP1(-/-) embryos show severe fetal anemia stemming from deficient erythropoietin (Epo) production and die midgestation. We determine that SENP1 controls Epo production ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VHL SUMO1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1108439 | |
| VHL SUMO1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 1108438 |
Curated By
- BioGRID