BAIT
MAP1LC3A
1010001H21Rik, 4922501H04Rik, LC3, LC3a, RP23-87L24.4
microtubule-associated protein 1 light chain 3 alpha
GO Process (6)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ATG7
1810013K23Rik, Agp7, Apg7l, Atg7l, Gm21553
autophagy related 7
GO Process (37)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- adult walking behavior [IMP]
- autophagy [IMP]
- cardiac muscle cell development [IMP]
- cellular amino acid metabolic process [IMP]
- cellular response to hyperoxia [ISO]
- cellular response to nitrogen starvation [IBA]
- cellular response to starvation [ISO]
- central nervous system neuron axonogenesis [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebral cortex development [IMP]
- late nucleophagy [IBA]
- liver development [IMP]
- macroautophagy [IBA]
- membrane organization [IMP]
- mitochondrion degradation [IBA]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of histone H4-K16 acetylation [IMP]
- negative stranded viral RNA replication [IMP]
- neurological system process [IMP]
- neuron projection development [IMP]
- organelle organization [IMP]
- piecemeal microautophagy of nucleus [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of macroautophagy [ISO]
- positive regulation of mucus secretion [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein modification process [IDA, ISO]
- post-embryonic development [IMP]
- protein catabolic process [IMP]
- protein lipidation [ISO]
- protein modification by small protein conjugation [IMP]
- pyramidal neuron development [IMP]
- regulation of protein ubiquitination [IMP]
- response to starvation [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions and leads to liver injury and neurodegeneration, but the details of abnormalities related to impaired autophagy are largely unknown. Here we used mouse genetic analyses to define the roles of autophagy in the aforementioned events. We report that the ubiquitin- and LC3-binding protein "p62" regulates the formation of protein ... [more]
Cell Dec. 14, 2007; 131(6);1149-63 [Pubmed: 18083104]
Throughput
- Low Throughput
Additional Notes
- table S1.
Curated By
- BioGRID