BAIT
POU5F1
NF-A3, Oct-3, Oct-3/4, Oct-4, Oct3, Oct3/4, Oct4, Otf-3, Otf-4, Otf3, Otf3-rs7, Otf3g, Otf4
POU domain, class 5, transcription factor 1
GO Process (33)
GO Function (18)
GO Component (8)
Gene Ontology Biological Process
- BMP signaling pathway involved in heart induction [ISO]
- blastocyst growth [IGI]
- cardiac cell fate determination [ISO]
- cell fate commitment [IMP]
- cell fate commitment involved in formation of primary germ layer [ISO]
- ectodermal cell fate commitment [IDA]
- endodermal cell fate commitment [IDA]
- endodermal cell fate specification [ISO]
- germ-line stem cell maintenance [IMP]
- mRNA transcription from RNA polymerase II promoter [IDA]
- mesodermal cell fate commitment [IDA]
- negative regulation of calcium ion-dependent exocytosis [IDA]
- negative regulation of cell differentiation [IGI]
- negative regulation of gene silencing by miRNA [ISO]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [ISO]
- regulation of heart induction by regulation of canonical Wnt signaling pathway [ISO]
- regulation of methylation-dependent chromatin silencing [ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to organic substance [IDA]
- response to retinoic acid [IDA]
- somatic stem cell maintenance [ISO]
- stem cell differentiation [IDA]
- stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- trophectodermal cell differentiation [IGI]
Gene Ontology Molecular Function- DNA binding [IDA, IGI, ISO]
- HMG box domain binding [ISO]
- POU domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- DNA binding [IDA, IGI, ISO]
- HMG box domain binding [ISO]
- POU domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
Mus musculus
PREY
CDH1
AA960649, E-cad, Ecad, L-CAM, UVO, Um
cadherin 1
GO Process (30)
GO Function (10)
GO Component (26)
Gene Ontology Biological Process
- adherens junction organization [ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cellular response to amino acid stimulus [IDA]
- cellular response to indole-3-methanol [ISO]
- cellular response to lithium ion [ISO]
- cochlea development [IMP]
- epithelial cell morphogenesis [IMP]
- establishment of protein localization to plasma membrane [IDA, ISO]
- in utero embryonic development [IMP]
- intestinal epithelial cell development [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of epithelial cell proliferation [IMP]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein homooligomerization [IDA]
- protein localization to plasma membrane [ISO]
- protein metabolic process [IDA]
- regulation of branching involved in salivary gland morphogenesis [IMP]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of neuron migration [IDA]
- regulation of protein localization [IMP]
- regulation of protein localization to cell surface [IMP]
- regulation of water loss via skin [IMP]
- salivary gland cavitation [IMP]
- sensory perception of sound [IMP]
- single organismal cell-cell adhesion [IMP, ISO]
- synapse assembly [ISO]
- tight junction assembly [IMP]
- trophectodermal cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- actin cytoskeleton [ISO]
- adherens junction [IDA]
- aggresome [ISO]
- apical junction complex [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA]
- axon terminus [IDA]
- basolateral plasma membrane [IDA]
- catenin complex [IDA, ISO]
- cell junction [ISO]
- cell periphery [IDA]
- cell surface [IDA]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of membrane [ISO]
- lateral loop [IDA]
- lateral plasma membrane [ISO]
- node of Ranvier [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- trans-Golgi network [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells.
The maintenance of pluripotency in mouse embryonic stem cells (mESCs) relies on the activity of a transcriptional network that is fuelled by the activity of three transcription factors (Nanog, Oct4 and Sox2) and balanced by the repressive activity of Tcf3. Extracellular signals modulate the activity of the network and regulate the differentiation capacity of the cells. Wnt/β-catenin signaling has emerged ... [more]
Development Mar. 01, 2013; 140(6);1171-83 [Pubmed: 23444350]
Throughput
- Low Throughput
Curated By
- BioGRID