BAIT

SPC72

LDB4, gamma-tubulin complex subunit SPC72, L000003455, YAL047C
Component of the cytoplasmic Tub4p (gamma-tubulin) complex; binds spindle pole bodies and links them to microtubules; is regulated by Cdc5 kinase; has roles in astral microtubule formation and stabilization
Saccharomyces cerevisiae (S288c)
PREY

BUB2

PAC7, L000000197, YMR055C
Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Spindle pole body history intrinsically links pole identity with asymmetric fate in budding yeast.

Juanes MA, Twyman H, Tunnacliffe E, Guo Z, ten Hoopen R, Segal M

Budding yeast is a unique model for exploring differential fate in a cell dividing asymmetrically. In yeast, spindle orientation begins with the old spindle pole body (SPB) (from the preceding cell cycle) contacting the bud by its existing astral microtubules (aMTs) while the new pole delays astral microtubule organization. This appears to prime the inheritance of the old pole by ... [more]

Curr. Biol. Jul. 22, 2013; 23(14);1310-9 [Pubmed: 23810537]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: mitotic cell cycle (APO:0000072)

Additional Notes

  • Expression of Spc721-276-Cnm67 elicited a moderate genetic interaction with a bub2 deletion mutation, allowing for the accumulation of cells exhibiting premature mitotic exit

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SPC72 BUB2
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
160886

Curated By

  • BioGRID