PSEN2
Gene Ontology Biological Process
- Notch receptor processing [IBA, TAS]
- Notch signaling pathway [TAS]
- amyloid precursor protein catabolic process [IBA, TAS]
- apoptotic signaling pathway [TAS]
- beta-amyloid metabolic process [IBA]
- calcium ion transport [IBA]
- membrane protein ectodomain proteolysis [IDA]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [IBA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of catalytic activity [IDA]
- protein processing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Z disc [IBA]
- apical plasma membrane [IBA]
- axon [IBA]
- cell cortex [IBA]
- cell surface [IBA]
- centrosome [IDA]
- ciliary rootlet [IBA]
- dendritic shaft [IBA]
- endoplasmic reticulum [IDA]
- growth cone [IBA]
- integral component of plasma membrane [IDA]
- kinetochore [IDA]
- lysosomal membrane [IBA]
- membrane [IDA]
- membrane raft [IBA]
- mitochondrial inner membrane [IBA]
- neuromuscular junction [IBA]
- neuronal cell body [IBA]
- nuclear inner membrane [IDA]
- perinuclear region of cytoplasm [IBA]
- plasma membrane [TAS]
- protein complex [IDA]
CIB1
Gene Ontology Biological Process
- apoptotic process [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to growth factor stimulus [ISS]
- cellular response to nerve growth factor stimulus [IDA]
- cellular response to tumor necrosis factor [IMP]
- cytoplasmic microtubule organization [IMP]
- double-strand break repair [TAS]
- endomitotic cell cycle [IDA]
- extrinsic apoptotic signaling pathway [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of megakaryocyte differentiation [ISS]
- negative regulation of microtubule depolymerization [IDA]
- negative regulation of neuron projection development [IDA]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein phosphorylation [ISS]
- platelet formation [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell growth [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of cell-matrix adhesion [ISS]
- positive regulation of establishment of protein localization to plasma membrane [IGI]
- positive regulation of male germ cell proliferation [ISS]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [ISS]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of cell division [IMP]
- regulation of cell proliferation [IMP]
- response to ischemia [ISS]
- spermatid development [ISS]
- thrombopoietin-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell periphery [IDA]
- centrosome [IDA]
- cytoplasm [IDA, IMP]
- endoplasmic reticulum [IMP]
- extracellular vesicular exosome [IDA]
- filopodium tip [IDA]
- growth cone [IDA]
- lamellipodium [IDA]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [IDA, IMP]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- sarcolemma [IDA]
- vesicle [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein.
It is well established that mutations in the presenilin 1 and 2 genes cause the majority of early onset Alzheimer's disease (AD). However, our understanding of the cellular functions of the proteins they encode remains rudimentary. Knowledge of proteins with which the presenilins interact should lead to a better understanding of presenilin function in normal and disease states. We report ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CIB1 PSEN2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 304810 | |
| CIB1 PSEN2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| PSEN2 CIB1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID