BAIT

LRRFIP1

AU024550, Fliiap1
leucine rich repeat (in FLII) interacting protein 1
GO Process (0)
GO Function (3)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

FLII

FLI, FLIL, Fli1
flightless I homolog (Drosophila)
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription.

Lee YH, Stallcup MR

Beta-catenin mediates Wnt/wingless signaling and transcriptional activation by lymphocyte enhancer binding factor 1/T cell factor (LEF1/TCF) proteins with the assistance of multiple coregulators, including positive cofactors like p300/CBP and negative cofactors like HDACs. We previously demonstrated that a developmentally essential protein, Flightless-I (Fli-I), serves as a coactivator for nuclear receptor-mediated transcription. To further understand the action mechanism of Fli-I, we ... [more]

Nucleic Acids Res. Sep. 23, 2006; 34(18);5052-9 [Pubmed: 16990252]

Throughput

  • Low Throughput

Additional Notes

  • figure 5. Fli-I inhibits the synergy of FLAP1 and p300 on transcription activation.

Curated By

  • BioGRID