BAIT

EPS15L1

EPS15R
epidermal growth factor receptor pathway substrate 15-like 1
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

AGFG2

HRBL, RABR, tcag7.884
ArfGAP with FG repeats 2
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport.

Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP

The Eps15 homology (EH) module is a protein-protein interaction domain that establishes a network of connections involved in various aspects of endocytosis and sorting. The finding that EH-containing proteins bind to Hrb (a cellular cofactor of the Rev protein) and to the related protein Hrbl raised the possibility that the EH network might also influence the so-called Rev export pathway, ... [more]

J. Cell Biol. Dec. 27, 1999; 147(7);1379-84 [Pubmed: 10613896]

Throughput

  • Low Throughput

Curated By

  • BioGRID