A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport.

Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP

The Eps15 homology (EH) module is a protein-protein interaction domain that establishes a network of connections involved in various aspects of endocytosis and sorting. The finding that EH-containing proteins bind to Hrb (a cellular cofactor of the Rev protein) and to the related protein Hrbl raised the possibility that the EH network might also influence the so-called Rev export pathway, ... [more]

J. Cell Biol. Dec. 27, 1999; 147(7);1379-84 [Pubmed: 10613896]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
AGFG2 EPS15	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Doria M (1999)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

EPS15

Gene Ontology Biological Process

Gene Ontology Molecular Function

polyubiquitin binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

AGFG2