BAIT
RNF8
3830404E21Rik, AIP37
ring finger protein 8
GO Process (16)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA, ISO]
- double-strand break repair [ISO]
- double-strand break repair via nonhomologous end joining [IMP]
- histone H2A K63-linked ubiquitination [ISO]
- histone H2A ubiquitination [IMP, ISO]
- histone H2B ubiquitination [IMP]
- histone exchange [IMP]
- isotype switching [IMP]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO]
- positive regulation of DNA repair [ISO]
- protein K48-linked ubiquitination [ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- response to ionizing radiation [ISO]
- spermatid development [IMP]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
UBE2N
1500026J17Rik, AL022654, BB101821, UBC13
ubiquitin-conjugating enzyme E2N
GO Process (14)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- DNA double-strand break processing [ISO]
- T cell receptor signaling pathway [ISO, ISS]
- double-strand break repair via homologous recombination [ISO]
- histone ubiquitination [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of histone modification [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- postreplication repair [IBA, ISO]
- protein K63-linked ubiquitination [IBA, ISO]
- protein ubiquitination [ISO]
- regulation of histone ubiquitination [ISO]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Chfr and RNF8 synergistically regulate ATM activation.
Protein ubiquitination is a crucial component of the DNA damage response. To study the mechanism of the DNA damage-induced ubiquitination pathway, we analyzed the impact of the loss of two E3 ubiquitin ligases, RNF8 and Chfr. Notably, DNA damage-induced activation of ATM kinase is suppressed in cells deficient in both RNF8 and Chfr (double-knockout, or DKO), and DKO mice develop ... [more]
Nat. Struct. Mol. Biol. Jul. 01, 2011; 18(7);761-8 [Pubmed: 21706008]
Throughput
- Low Throughput
Additional Notes
- figure S4a.
Curated By
- BioGRID