BAIT
CHFR
5730484M20Rik, C230082M18, RNF116
checkpoint with forkhead and ring finger domains
GO Process (9)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- mitotic cell cycle [IMP]
- mitotic cell cycle checkpoint [ISO]
- modification-dependent protein catabolic process [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein destabilization [IDA]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [IMP]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Mus musculus
PREY
UBE2V1
0610011J09Rik, AI256840, CROC-1, CROC1, D7Bwg1382e, UEV-1, RP23-118A2.7
ubiquitin-conjugating enzyme E2 variant 1
GO Process (4)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Chfr and RNF8 synergistically regulate ATM activation.
Protein ubiquitination is a crucial component of the DNA damage response. To study the mechanism of the DNA damage-induced ubiquitination pathway, we analyzed the impact of the loss of two E3 ubiquitin ligases, RNF8 and Chfr. Notably, DNA damage-induced activation of ATM kinase is suppressed in cells deficient in both RNF8 and Chfr (double-knockout, or DKO), and DKO mice develop ... [more]
Nat. Struct. Mol. Biol. Jul. 01, 2011; 18(7);761-8 [Pubmed: 21706008]
Throughput
- Low Throughput
Additional Notes
- figure S4a.
Curated By
- BioGRID