BAIT

FLT1

FLT, FLT-1, VEGFR-1, VEGFR1
fms-related tyrosine kinase 1
GO Process (20)
GO Function (7)
GO Component (5)
Homo sapiens
PREY

SHC1

SHC, SHCA, RP11-307C12.1
SHC (Src homology 2 domain containing) transforming protein 1
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.

Warner AJ, Lopez-Dee J, Knight EL, Feramisco JR, Prigent SA

Despite much progress in recent years, the precise signalling events triggered by the vascular-endothelial-growth-factor (VEGF) receptors, fms-like tyrosine kinase (Flt1) and kinase insert domain-containing receptor (KDR), are incompletely defined. Results obtained when Flt1 and KDR are individually expressed in fibroblasts or porcine aortic endothelial cells have not been entirely consistent with those observed in other endothelial cells expressing both receptors ... [more]

Biochem. J. Apr. 15, 2000; 347(0);501-9 [Pubmed: 10749680]

Throughput

  • Low Throughput

Curated By

  • BioGRID