BAIT
TGFBR1
AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, RP11-96L7.1
transforming growth factor, beta receptor 1
GO Process (43)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPKK activity [IDA]
- anterior/posterior pattern specification [ISS]
- artery morphogenesis [ISS]
- cell cycle arrest [TAS]
- cell motility [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- collagen fibril organization [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- epithelial to mesenchymal transition [IDA]
- extracellular structure organization [TAS]
- germ cell migration [ISS]
- heart development [ISS]
- in utero embryonic development [ISS]
- kidney development [ISS]
- mesenchymal cell differentiation [TAS]
- negative regulation of chondrocyte differentiation [ISS]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- neuron fate commitment [ISS]
- palate development [ISS]
- parathyroid gland development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pharyngeal system development [ISS]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of protein ubiquitination [IDA]
- regulation of transcription, DNA-templated [IDA, IMP]
- response to cholesterol [IDA]
- signal transduction [IDA]
- skeletal system development [ISS]
- skeletal system morphogenesis [ISS]
- thymus development [ISS]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- wound healing [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- I-SMAD binding [IPI]
- SMAD binding [IDA, IPI]
- growth factor binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA, IMP, IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- type II transforming growth factor beta receptor binding [IDA, IPI]
- ATP binding [IDA]
- I-SMAD binding [IPI]
- SMAD binding [IDA, IPI]
- growth factor binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA, IMP, IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- type II transforming growth factor beta receptor binding [IDA, IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
BMPR2
2610024H22Rik, AL117858, AW546137, BB189135, BMP-2, BMPR-2, BMPR-II, BMPRII, BRK-3, Gm20272
bone morphogenetic protein receptor, type II (serine/threonine kinase)
GO Process (33)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- anterior/posterior pattern specification [IGI, IMP]
- artery development [IMP]
- blood vessel remodeling [IMP]
- chondrocyte development [ISO]
- limb development [IGI]
- lung alveolus development [IMP]
- lymphangiogenesis [IMP]
- lymphatic endothelial cell differentiation [IMP]
- maternal placenta development [IMP]
- mesoderm formation [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of chondrocyte proliferation [ISO]
- negative regulation of systemic arterial blood pressure [ISO]
- negative regulation of vasoconstriction [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of bone mineralization [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of cell proliferation [ISO]
- regulation of lung blood pressure [IMP, ISO]
- retina vasculature development in camera-type eye [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP]
- venous blood vessel development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
High-throughput mapping of a dynamic signaling network in mammalian cells.
Signaling pathways transmit information through protein interaction networks that are dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-based mammalian interactome mapping), an automated high-throughput technology, to map protein-protein interaction networks systematically in mammalian cells and applied it to the transforming growth factor-beta (TGFbeta) pathway. Analysis using self-organizing maps and k-means clustering identified links of the TGFbeta pathway ... [more]
Science Mar. 11, 2005; 307(5715);1621-5 [Pubmed: 15761153]
Throughput
- High Throughput
Curated By
- BioGRID