ACVR1
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- G1/S transition of mitotic cell cycle [IMP]
- activin receptor signaling pathway [IDA]
- atrial septum primum morphogenesis [IMP]
- cardiac muscle cell fate commitment [IMP]
- embryonic heart tube morphogenesis [IMP]
- endocardial cushion cell fate commitment [IMP]
- mitral valve morphogenesis [IMP]
- negative regulation of activin receptor signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of signal transduction [IMP]
- pathway-restricted SMAD protein phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of ossification [IMP]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA]
- peptide hormone binding [NAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA]
- peptide hormone binding [NAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
Gene Ontology Cellular Component
FKBP4
Gene Ontology Biological Process
- androgen receptor signaling pathway [IMP]
- chaperone-mediated protein folding [IBA, ISO]
- copper ion transport [ISO]
- embryo implantation [IMP]
- male sex differentiation [IMP]
- negative regulation of microtubule polymerization [ISO]
- prostate gland development [IMP]
- protein complex localization [IDA]
- protein peptidyl-prolyl isomerization [IBA, ISO]
- reproductive structure development [IMP]
- steroid hormone receptor complex assembly [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- FK506 binding [IBA]
- GTP binding [IDA]
- copper-dependent protein binding [ISO]
- glucocorticoid receptor binding [IDA]
- heat shock protein binding [IDA, ISO]
- peptidyl-prolyl cis-trans isomerase activity [IBA, ISO]
- phosphoprotein binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
- ATP binding [IDA]
- FK506 binding [IBA]
- GTP binding [IDA]
- copper-dependent protein binding [ISO]
- glucocorticoid receptor binding [IDA]
- heat shock protein binding [IDA, ISO]
- peptidyl-prolyl cis-trans isomerase activity [IBA, ISO]
- phosphoprotein binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
High-throughput mapping of a dynamic signaling network in mammalian cells.
Signaling pathways transmit information through protein interaction networks that are dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-based mammalian interactome mapping), an automated high-throughput technology, to map protein-protein interaction networks systematically in mammalian cells and applied it to the transforming growth factor-beta (TGFbeta) pathway. Analysis using self-organizing maps and k-means clustering identified links of the TGFbeta pathway ... [more]
Throughput
- High Throughput
Curated By
- BioGRID