CBX3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- chromatin [IDA, ISO]
- chromocenter [IDA]
- condensed chromosome, centromeric region [IDA]
- nuclear envelope [IDA]
- nuclear euchromatin [ISO]
- nuclear heterochromatin [IDA, ISO]
- nuclear pericentric heterochromatin [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- senescence-associated heterochromatin focus [ISO]
- spindle [ISO]
HDAC9
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- cellular response to insulin stimulus [ISO]
- chromatin modification [TAS]
- heart development [IGI]
- histone H3 deacetylation [ISO]
- histone H4 deacetylation [ISO]
- histone deacetylation [ISO, TAS]
- inflammatory response [TAS]
- negative regulation of striated muscle tissue development [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO, TAS]
- nervous system development [TAS]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of cell migration involved in sprouting angiogenesis [ISO]
- regulation of skeletal muscle fiber development [IGI]
- regulation of striated muscle cell differentiation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.
Class II histone deacetylases (HDACs) 4, 5, 7, and 9 repress muscle differentiation through associations with the myocyte enhancer factor 2 (MEF2) transcription factor. MEF2-interacting transcription repressor (MITR) is an amino-terminal splice variant of HDAC9 that also potently inhibits MEF2 transcriptional activity despite lacking a catalytic domain. Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID