BAIT
CTNNB1
CTNNB, MRD19, armadillo, OK/SW-cl.35
catenin (cadherin-associated protein), beta 1, 88kDa
GO Process (48)
GO Function (20)
GO Component (23)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- adherens junction assembly [IMP]
- androgen receptor signaling pathway [NAS]
- apoptotic process [TAS]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [ISS]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [IMP]
- cell adhesion [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to growth factor stimulus [IMP]
- cellular response to indole-3-methanol [IDA]
- embryonic skeletal limb joint morphogenesis [ISS]
- endothelial tube morphogenesis [IMP]
- epithelial to mesenchymal transition [TAS]
- hair cell differentiation [TAS]
- innate immune response [TAS]
- muscle cell differentiation [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of mitotic cell cycle, embryonic [ISS]
- negative regulation of protein sumoylation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- patterning of blood vessels [IC]
- positive regulation of DNA-templated transcription, initiation [IC]
- positive regulation of apoptotic process [IDA]
- positive regulation of epithelial to mesenchymal transition [IGI]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [IMP]
- positive regulation of histone H3-K4 methylation [IC]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- protein localization to cell surface [IMP]
- regulation of angiogenesis [TAS]
- regulation of calcium ion import [IDA]
- regulation of cell fate specification [IBA]
- regulation of centriole-centriole cohesion [IDA]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of fibroblast proliferation [TAS]
- regulation of nephron tubule epithelial cell differentiation [ISS]
- regulation of protein localization to cell surface [IDA]
- regulation of smooth muscle cell proliferation [IMP]
- response to drug [IEP]
- response to estradiol [IDA]
- single organismal cell-cell adhesion [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [ISS]
Gene Ontology Molecular Function- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- SMAD binding [IPI]
- alpha-catenin binding [IPI]
- androgen receptor binding [NAS]
- cadherin binding [IPI]
- enzyme binding [IPI]
- estrogen receptor binding [IPI]
- euchromatin binding [IDA]
- ion channel binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- signal transducer activity [NAS]
- transcription coactivator activity [IDA, IMP]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- SMAD binding [IPI]
- alpha-catenin binding [IPI]
- androgen receptor binding [NAS]
- cadherin binding [IPI]
- enzyme binding [IPI]
- estrogen receptor binding [IPI]
- euchromatin binding [IDA]
- ion channel binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- signal transducer activity [NAS]
- transcription coactivator activity [IDA, IMP]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- adherens junction [IDA]
- beta-catenin destruction complex [IDA]
- beta-catenin-TCF7L2 complex [IDA]
- catenin complex [IDA]
- cell cortex [IDA]
- cell junction [IDA, TAS]
- cell periphery [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- lateral plasma membrane [IDA]
- membrane [ISS]
- nuclear euchromatin [IDA]
- nucleoplasm [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- protein-DNA complex [IDA]
- transcription factor complex [IDA]
Homo sapiens
PREY
TCF7L2
TCF4B, TCF4E, Tcf-4, Tcf4, mTcf-4B, mTcf-4E
transcription factor 7 like 2, T cell specific, HMG box
GO Process (63)
GO Function (15)
GO Component (10)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IGI]
- blood vessel development [ISO]
- bone mineralization [IGI]
- canonical Wnt signaling pathway [IMP]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [ISO]
- catenin import into nucleus [IDA]
- cell cycle arrest [ISO]
- cell proliferation [ISO]
- cellular glucose homeostasis [IMP]
- cellular response to starvation [IMP]
- embryonic digestive tract morphogenesis [IGI]
- embryonic genitalia morphogenesis [IGI]
- embryonic hindgut morphogenesis [IGI]
- face morphogenesis [IGI]
- fat cell differentiation [ISO]
- glucose homeostasis [IMP, ISO]
- glucose metabolic process [IMP]
- glycogen metabolic process [IMP]
- insulin metabolic process [IMP]
- maintenance of DNA repeat elements [ISO]
- multicellular organism growth [IMP]
- myoblast fate commitment [IMP, ISO]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast growth factor receptor signaling pathway [IMP]
- negative regulation of organ growth [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of type B pancreatic cell apoptotic process [ISO]
- neural tube development [IGI]
- odontogenesis of dentin-containing tooth [IGI]
- oligodendrocyte development [IMP]
- pituitary gland development [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of gluconeogenesis [IMP]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [ISO]
- positive regulation of insulin secretion [IMP, ISO]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of protein binding [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of triglyceride biosynthetic process [IMP]
- post-embryonic development [IMP]
- regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of hormone metabolic process [ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
- regulation of myelination [IMP]
- regulation of oligodendrocyte differentiation [IMP]
- regulation of skeletal muscle tissue development [IMP]
- regulation of smooth muscle cell proliferation [ISO]
- regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- regulation of transcription, DNA-templated [IBA, IDA]
- response to glucose [IMP]
- secretory granule localization [IMP]
- skin development [IGI]
- somatic stem cell maintenance [IGI, IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [ISO]
- armadillo repeat domain binding [ISO]
- beta-catenin binding [IDA, IPI, ISO]
- chromatin binding [IDA, IGI]
- gamma-catenin binding [ISO]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IBA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [ISO]
- armadillo repeat domain binding [ISO]
- beta-catenin binding [IDA, IPI, ISO]
- chromatin binding [IDA, IGI]
- gamma-catenin binding [ISO]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IBA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors.
We have cloned T-cell factor 4N (TCF-4N), an alternative isoform of TCF-4, from developing pituitary and 3T3-L1 preadipocytes. This protein contains the N-terminal interaction domain for beta-catenin but lacks the DNA binding domain. While TCF-4N inhibited coactivation by beta-catenin of a TCF/lymphoid-enhancing factor (LEF)-dependent promoter, TCF-4N potentiated coactivation by beta-catenin of several non-TCF/LEF-dependent promoters. For example, TCF-4N synergized with beta-catenin ... [more]
Mol. Cell. Biol. Aug. 01, 2003; 23(15);5366-75 [Pubmed: 12861022]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal protein level (MP:0008469)
- phenotype: abnormal adipose tissue amount (MP:0005452)
Additional Notes
- Co-transfection of mutated Tcf7l2 blocks the reporter activation seen upon overexpression of Beta catenin
- co-transfection of Tcf7l2 inhibits the differentiation block seen in preadipocytes expressing beta catenin
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CTNNB1 TCF7L2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1172748 | |
| CTNNB1 TCF7L2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1172746 |
Curated By
- BioGRID