BMPR1B
Gene Ontology Biological Process
- BMP signaling pathway [IDA, NAS, TAS]
- cartilage condensation [NAS]
- eye development [ISS]
- limb morphogenesis [IMP]
- ovarian cumulus expansion [ISS]
- ovulation cycle [ISS]
- positive regulation of bone mineralization [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of osteoblast differentiation [IMP]
- protein phosphorylation [IDA]
- skeletal system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BMPR2
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- anterior/posterior pattern specification [IGI, IMP]
- artery development [IMP]
- blood vessel remodeling [IMP]
- chondrocyte development [ISO]
- limb development [IGI]
- lung alveolus development [IMP]
- lymphangiogenesis [IMP]
- lymphatic endothelial cell differentiation [IMP]
- maternal placenta development [IMP]
- mesoderm formation [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of chondrocyte proliferation [ISO]
- negative regulation of systemic arterial blood pressure [ISO]
- negative regulation of vasoconstriction [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of bone mineralization [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of cell proliferation [ISO]
- regulation of lung blood pressure [IMP, ISO]
- retina vasculature development in camera-type eye [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP]
- venous blood vessel development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
High-throughput mapping of a dynamic signaling network in mammalian cells.
Signaling pathways transmit information through protein interaction networks that are dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-based mammalian interactome mapping), an automated high-throughput technology, to map protein-protein interaction networks systematically in mammalian cells and applied it to the transforming growth factor-beta (TGFbeta) pathway. Analysis using self-organizing maps and k-means clustering identified links of the TGFbeta pathway ... [more]
Throughput
- High Throughput
Curated By
- BioGRID