NUP100
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IGI]
- mRNA export from nucleus [IPI]
- mRNA export from nucleus in response to heat stress [IMP]
- positive regulation of transcription, DNA-templated [IGI]
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
- protein import into nucleus [IGI]
- protein targeting to nuclear inner membrane [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GSP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae.
The eukaryotic nuclear permeability barrier and selective nucleocytoplasmic transport are maintained by nuclear pore complexes (NPCs), large structures composed of ∼ 30 proteins (nucleoporins [Nups]). NPC structure and function are disrupted in aged nondividing metazoan cells, although it is unclear whether these changes are a cause or consequence of aging. Using the replicative life span (RLS) of Saccharomyces cerevisiae as ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: replicative lifespan (APO:0000317)
Additional Notes
- Inhibition of GSP1 function using the gsp1-322 mutant largely suppressed the extended RLSs of nup100 mutant cells
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
NUP100 GSP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1292 | BioGRID | 2053752 |
Curated By
- BioGRID