ESR1
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- chromatin remodeling [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [NAS]
- intracellular steroid hormone receptor signaling pathway [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phospholipase C activity [ISS]
- positive regulation of retinoic acid receptor signaling pathway [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [NAS]
- response to estradiol [IDA]
- response to estrogen [IDA]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- beta-catenin binding [IPI]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [NAS]
- estrogen response element binding [IDA]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IGI]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [NAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- steroid binding [ISS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- beta-catenin binding [IPI]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [NAS]
- estrogen response element binding [IDA]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IGI]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [NAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- steroid binding [ISS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
VCP
Gene Ontology Biological Process
- DNA repair [NAS]
- ER-associated ubiquitin-dependent protein catabolic process [IDA, IMP, TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment of protein localization [TAS]
- positive regulation of Lys63-specific deubiquitinase activity [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein K63-linked deubiquitination [IDA]
- positive regulation of protein catabolic process [IDA]
- positive regulation of protein complex assembly [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [NAS]
- protein N-linked glycosylation via asparagine [IMP]
- protein ubiquitination [IDA, NAS]
- regulation of apoptotic process [TAS]
- retrograde protein transport, ER to cytosol [IDA]
- translesion synthesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [ISS]
- lipid particle [IDA]
- nucleoplasm [IDA]
- nucleus [IDA, TAS]
- perinuclear region of cytoplasm [IDA]
- proteasome complex [IDA]
- site of double-strand break [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Proteomics analysis of the estrogen receptor alpha receptosome.
The estrogen receptors (ERs) are ligand-dependent transcription factors that activate transcription by binding to estrogen response elements. Estrogen-mediated effects are tissue- and cell type-specific, determined by the cofactor recruitment to the ERs among other factors. To understand these differences in estrogen action, it is important to identify the various compositions of the ER complexes (ER receptosomes). In this report, we ... [more]
Throughput
- High Throughput
Curated By
- BioGRID