FBXW11
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- mitotic cell cycle [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of circadian rhythm [ISS]
- positive regulation of proteolysis [IMP]
- positive regulation of transcription, DNA-templated [ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein dephosphorylation [ISS]
- protein destabilization [IMP]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
REST
Gene Ontology Biological Process
- cardiac muscle cell myoblast differentiation [ISS]
- cellular response to drug [IMP]
- cellular response to electrical stimulus [IMP]
- cellular response to glucocorticoid stimulus [IDA]
- histone H4 deacetylation [IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of aldosterone biosynthetic process [IMP]
- negative regulation of amniotic stem cell differentiation [IMP]
- negative regulation of calcium ion-dependent exocytosis [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of cortisol biosynthetic process [IMP]
- negative regulation of dense core granule biogenesis [ISS]
- negative regulation of gene expression [IMP]
- negative regulation of insulin secretion [IMP]
- negative regulation of mesenchymal stem cell differentiation [IMP]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, TAS]
- negative regulation of transcription, DNA-templated [IDA, IMP, NAS]
- positive regulation of apoptotic process [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- potassium ion transmembrane transport [IMP]
- regulation of transcription, DNA-templated [NAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin binding [ISS]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- outward rectifier potassium channel activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin binding [ISS]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- outward rectifier potassium channel activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.
The identification of ubiquitin E3 ligase substrates has been challenging, due in part to low-affinity, transient interactions, the rapid degradation of targets and the inability to identify proteins from poorly soluble cellular compartments. SCF(β-TrCP1) and SCF(β-TrCP2) are well-studied ubiquitin E3 ligases that target substrates for proteasomal degradation, and play important roles in Wnt, Hippo, and NFκB signaling. Combining 26S proteasome ... [more]
Throughput
- High Throughput
Additional Notes
- in the presence of MG132
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FBXW11 REST | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| FBXW11 REST | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| FBXW11 REST | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| FBXW11 REST | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FBXW11 REST | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FBXW11 REST | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID