BAIT
SORL1
C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250
sortilin-related receptor, L(DLR class) A repeats containing
GO Process (26)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- negative regulation of MAP kinase activity [ISS]
- negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [IDA, IMP]
- negative regulation of beta-amyloid formation [IDA, IMP]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [IMP]
- negative regulation of neurofibrillary tangle assembly [ISS]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron death [ISS]
- negative regulation of protein binding [IDA]
- negative regulation of protein oligomerization [IMP]
- negative regulation of tau-protein kinase activity [ISS]
- positive regulation of ER to Golgi vesicle-mediated transport [IMP]
- positive regulation of choline O-acetyltransferase activity [ISS]
- positive regulation of early endosome to recycling endosome transport [IMP]
- positive regulation of endocytic recycling [IMP]
- positive regulation of protein catabolic process [IDA]
- positive regulation of protein exit from endoplasmic reticulum [IMP]
- positive regulation of protein localization to early endosome [IMP]
- post-Golgi vesicle-mediated transport [IDA]
- protein maturation [IDA]
- protein retention in Golgi apparatus [IDA]
- protein targeting [IDA, IMP]
- protein targeting to Golgi [IDA]
- protein targeting to lysosome [IDA]
- receptor-mediated endocytosis [TAS]
- regulation of smooth muscle cell migration [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi cisterna [IDA]
- early endosome [IDA, IMP]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- membrane [IDA]
- nuclear envelope lumen [IDA]
- recycling endosome [IMP]
- trans-Golgi network [IDA]
Homo sapiens
PREY
APP
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- axon cargo transport [ISS]
- axon midline choice point recognition [ISS]
- axonogenesis [ISS]
- blood coagulation [TAS]
- cellular copper ion homeostasis [ISS]
- collateral sprouting in absence of injury [ISS]
- dendrite development [ISS]
- endocytosis [ISS]
- extracellular matrix organization [ISS, TAS]
- innate immune response [TAS]
- ionotropic glutamate receptor signaling pathway [ISS]
- locomotory behavior [ISS]
- mRNA polyadenylation [ISS]
- mating behavior [ISS]
- negative regulation of endopeptidase activity [IDA]
- neuron apoptotic process [IMP]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of mitotic cell cycle [ISS]
- protein phosphorylation [ISS]
- regulation of epidermal growth factor-activated receptor activity [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of synapse structure or activity [ISS]
- regulation of translation [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISS]
- axon [ISS]
- cell surface [IDA]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [ISS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- nuclear envelope lumen [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule lumen [TAS]
- receptor complex [IDA]
- synapse [IDA]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.
SorLA has been recognized as a novel sorting receptor that regulates trafficking and processing of the amyloid precursor protein (APP) and that represents a significant risk factor for sporadic Alzheimer disease. Here, we investigated the cellular mechanisms that control intracellular trafficking of sorLA and their relevance for APP processing. We demonstrate that sorLA acts as a retention factor for APP ... [more]
J. Biol. Chem. Nov. 09, 2007; 282(45);32956-64 [Pubmed: 17855360]
Throughput
- Low Throughput
Curated By
- BioGRID