NET1
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to ionizing radiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of apoptotic process [IDA, TAS]
- regulation of cell growth [NAS]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
DLG1
Gene Ontology Biological Process
- T cell activation [IMP]
- T cell cytokine production [IMP]
- actin filament organization [ISO]
- activation of protein kinase activity [IMP]
- amyloid precursor protein metabolic process [IGI]
- branching involved in ureteric bud morphogenesis [IMP]
- cortical actin cytoskeleton organization [ISO]
- embryonic skeletal system morphogenesis [IMP]
- endothelial cell proliferation [ISO]
- establishment or maintenance of epithelial cell apical/basal polarity [IBA]
- hard palate development [IMP]
- immunological synapse formation [IMP]
- lens development in camera-type eye [IMP]
- membrane raft organization [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein kinase B signaling [IMP]
- nucleotide phosphorylation [IBA]
- peristalsis [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of developmental growth [TAS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of potassium ion transport [ISO]
- protein localization [IGI, IMP]
- protein localization to plasma membrane [ISO]
- receptor clustering [IBA]
- receptor localization to synapse [IBA]
- regulation of membrane potential [IGI, ISO]
- regulation of myelination [IMP]
- regulation of protein localization [ISO]
- reproductive structure development [IMP]
- single organismal cell-cell adhesion [ISO]
- smooth muscle tissue development [IMP]
- synaptic transmission [IBA]
- tight junction assembly [ISO]
- tissue morphogenesis [IMP]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MPP7-DLG1-LIN7 complex [ISO]
- T-tubule [ISO]
- basal lamina [IDA]
- basal plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO, TAS]
- cell junction [IDA, ISO]
- cell projection membrane [IDA]
- cell-cell adherens junction [TAS]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- ionotropic glutamate receptor complex [IBA]
- lateral loop [IDA]
- lateral plasma membrane [IDA]
- membrane raft [IDA]
- microtubule [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- node of Ranvier [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA]
- presynaptic membrane [ISO]
- synapse [IDA]
- tight junction [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.
Net1 is a RhoA-specific guanine nucleotide exchange factor which localizes to the nucleus at steady state. A deletion in its N terminus redistributes the protein to the cytosol, where it activates RhoA and can promote transformation. Net1 contains a PDZ-binding motif at the C terminus which is essential for its transformation properties. Here, we found that Net1 interacts through its ... [more]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID