BAIT
NET1
ARHGEF8, NET1A, RP11-116G8.1
neuroepithelial cell transforming 1
GO Process (10)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to ionizing radiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of apoptotic process [IDA, TAS]
- regulation of cell growth [NAS]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
MPP2
D11Bwg0652e, Dlg2, Dlgh2, Pals4, RP23-398F7.8
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
GO Process (0)
GO Function (2)
GO Component (0)
Gene Ontology Molecular Function
Mus musculus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.
Net1 is a RhoA-specific guanine nucleotide exchange factor which localizes to the nucleus at steady state. A deletion in its N terminus redistributes the protein to the cytosol, where it activates RhoA and can promote transformation. Net1 contains a PDZ-binding motif at the C terminus which is essential for its transformation properties. Here, we found that Net1 interacts through its ... [more]
Mol. Cell. Biol. Dec. 01, 2007; 27(24);8683-97 [Pubmed: 17938206]
Throughput
- Low Throughput
Curated By
- BioGRID