BAIT
H2AFX
AW228881, H2A.X, H2ax, Hist5-2ax, gammaH2ax
H2A histone family, member X
GO Process (6)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA2
70kDa, HSP70.2, HSP70A2, Hsp70-2
heat shock protein 2
GO Process (8)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- male meiosis [IMP]
- male meiosis I [IMP]
- negative regulation of inclusion body assembly [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- positive regulation of protein phosphorylation [IMP]
- protein refolding [ISO]
- spermatid development [IMP]
- synaptonemal complex disassembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.
Gametogenesis is dependent on the expression of germline-specific genes. However, it remains unknown how the germline epigenome is distinctly established from that of somatic lineages. Here we show that genes commonly expressed in somatic lineages and spermatogenesis-progenitor cells undergo repression in a genome-wide manner in late stages of the male germline and identify underlying mechanisms. SCML2, a germline-specific subunit of ... [more]
Dev. Cell Mar. 09, 2015; 32(5);574-88 [Pubmed: 25703348]
Throughput
- Low Throughput
Curated By
- BioGRID