BAIT
CSNK2A1
CK2A1, CKII, CSNK2A3
casein kinase 2, alpha 1 polypeptide
GO Process (11)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- axon guidance [TAS]
- chaperone-mediated protein folding [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle checkpoint [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein catabolic process [IDA]
- protein phosphorylation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BHLHE41
BHLHB3, DEC2, SHARP1, hDEC2
basic helix-loop-helix family, member e41
GO Process (7)
GO Function (13)
GO Component (0)
Gene Ontology Biological Process
- cell differentiation [NAS]
- cell proliferation [NAS]
- negative regulation of myotube differentiation [ISS]
- negative regulation of transcription by competitive promoter binding [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- organ morphogenesis [NAS]
Gene Ontology Molecular Function- E-box binding [IDA, ISS]
- MRF binding [ISS]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISS]
- bHLH transcription factor binding [IPI, ISS]
- histone deacetylase binding [ISS]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISS]
- protein homodimerization activity [ISS]
- transcription corepressor activity [IDA]
- E-box binding [IDA, ISS]
- MRF binding [ISS]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISS]
- bHLH transcription factor binding [IPI, ISS]
- histone deacetylase binding [ISS]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISS]
- protein homodimerization activity [ISS]
- transcription corepressor activity [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
Essentially all biological processes depend on protein-protein interactions (PPIs). Timing of such interactions is crucial for regulatory function. Although circadian (~24-hour) clocks constitute fundamental cellular timing mechanisms regulating important physiological processes, PPI dynamics on this timescale are largely unknown. Here, we identified 109 novel PPIs among circadian clock proteins via a yeast-two-hybrid approach. Among them, the interaction of protein phosphatase ... [more]
PLoS Genet. Mar. 01, 2013; 9(3);e1003398 [Pubmed: 23555304]
Throughput
- Low Throughput
Curated By
- BioGRID