BAIT
CSNK1E
CKIepsilon, HCKIE, RP1-5O6.1
casein kinase 1, epsilon
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA, ISS]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
RORA
NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
RAR-related orphan receptor A
GO Process (25)
GO Function (10)
GO Component (2)
Gene Ontology Biological Process
- T-helper 17 cell differentiation [ISS]
- angiogenesis [IMP]
- cellular response to hypoxia [IMP]
- cellular response to sterol [IDA, IMP]
- cerebellar granule cell precursor proliferation [ISS]
- circadian regulation of gene expression [ISS]
- gene expression [TAS]
- intracellular receptor signaling pathway [IDA]
- muscle cell differentiation [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of inflammatory response [IMP]
- positive regulation of circadian rhythm [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation vascular endothelial growth factor production [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of glucose metabolic process [ISS]
- regulation of smoothened signaling pathway [ISS]
- regulation of steroid metabolic process [ISS]
- regulation of transcription involved in cell fate commitment [ISS]
- regulation of transcription, DNA-templated [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- triglyceride homeostasis [IMP]
- xenobiotic metabolic process [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- direct ligand regulated sequence-specific DNA binding transcription factor activity [IDA]
- oxysterol binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator binding [IPI]
- transcription corepressor binding [IPI]
- transcription factor binding [IPI]
- DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- direct ligand regulated sequence-specific DNA binding transcription factor activity [IDA]
- oxysterol binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator binding [IPI]
- transcription corepressor binding [IPI]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
Essentially all biological processes depend on protein-protein interactions (PPIs). Timing of such interactions is crucial for regulatory function. Although circadian (~24-hour) clocks constitute fundamental cellular timing mechanisms regulating important physiological processes, PPI dynamics on this timescale are largely unknown. Here, we identified 109 novel PPIs among circadian clock proteins via a yeast-two-hybrid approach. Among them, the interaction of protein phosphatase ... [more]
PLoS Genet. Mar. 01, 2013; 9(3);e1003398 [Pubmed: 23555304]
Throughput
- Low Throughput
Curated By
- BioGRID