ARNTL2
Gene Ontology Biological Process
- circadian rhythm [IDA]
- entrainment of circadian clock [NAS]
- positive regulation of circadian rhythm [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [NAS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
UBE3A
Gene Ontology Biological Process
- androgen receptor signaling pathway [IBA]
- brain development [TAS]
- protein K48-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- proteolysis [TAS]
- regulation of circadian rhythm [IMP]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ube3a imprinting impairs circadian robustness in Angelman syndrome models.
The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal Ube3a allele, which thereby eliminates Ube3a neuronal expression. Sleep disorders such as short sleep duration and increased sleep onset latency are very common in AS.We found a unique link between neuronal imprinting of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID