TBX5
Gene Ontology Biological Process
- apoptotic nuclear changes [ISO]
- atrial septum development [IMP]
- atrial septum morphogenesis [IGI]
- atrioventricular valve morphogenesis [IGI]
- bundle of His development [IGI]
- cardiac left ventricle formation [IMP]
- cardiac muscle cell differentiation [IGI, IMP]
- cell-cell signaling [ISO]
- embryonic forelimb morphogenesis [IMP, ISO]
- embryonic limb morphogenesis [IGI, IMP, ISO]
- endocardial cushion development [IGI]
- forelimb morphogenesis [IMP, ISO]
- heart development [IMP, ISO]
- lung development [IMP]
- morphogenesis of an epithelium [IMP]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- pattern specification process [IMP]
- pericardium development [ISO]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cardioblast differentiation [ISO]
- positive regulation of secondary heart field cardioblast proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription, DNA-templated [IMP]
- transcription from RNA polymerase II promoter [IDA]
- transdifferentiation [ISO]
- ventricular cardiac muscle tissue development [IGI]
- ventricular septum development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development.
The ubiquitin-proteasome system (UPS) plays an important role in protein quality control, cellular signalings, and cell differentiation through the regulated turnover of key transcription factors in cardiac tissue. However, the molecular mechanism underlying Fbxo25-mediated ubiquitination of cardiac transcription factors remains elusive. We report that an Fbxo25-mediated SCF ubiquitination pathway regulates the protein levels and activities of Tbx5 and Nkx2-5 based ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID