VTI1B
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IBA]
- Golgi to vacuole transport [IBA]
- autophagic vacuole fusion [IMP]
- cell proliferation [TAS]
- intra-Golgi vesicle-mediated transport [IBA]
- membrane fusion [TAS]
- protein targeting to vacuole [IBA]
- regulation of protein localization to plasma membrane [IDA]
- retrograde transport, endosome to Golgi [IBA]
- vesicle docking involved in exocytosis [TAS]
- vesicle fusion with Golgi apparatus [IBA]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [IBA]
- Golgi apparatus [IDA]
- SNARE complex [IBA]
- cytoplasm [IDA]
- endoplasmic reticulum membrane [IBA]
- intracellular membrane-bounded organelle [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- neuronal cell body [ISS]
- perinuclear region of cytoplasm [IDA]
- recycling endosome [IDA]
- synaptic vesicle [ISS]
- vesicle [IDA]
VPS45
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.998758051 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.998758051, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VTI1B VPS45 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9601 | BioGRID | 2249852 | |
| VTI1B VPS45 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9843 | BioGRID | 3107372 | |
| VTI1B VPS45 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9839 | BioGRID | 3294549 |
Curated By
- BioGRID