GAS6
Gene Ontology Biological Process
- B cell chemotaxis [IDA]
- activation of protein kinase B activity [ISS]
- apoptotic cell clearance [IDA]
- blood coagulation [TAS]
- calcium ion transmembrane transport [IDA]
- cell adhesion [TAS]
- cell cycle arrest [TAS]
- cell migration [TAS]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to drug [IDA]
- cellular response to glucose stimulus [ISS]
- cellular response to interferon-alpha [IDA]
- cellular response to vitamin K [IDA]
- dendritic cell differentiation [IEP]
- extracellular matrix assembly [ISS]
- fusion of virus membrane with host plasma membrane [IDA]
- hematopoietic stem cell migration to bone marrow [IDA]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of biomineral tissue development [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-1 secretion [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-6 secretion [IDA]
- negative regulation of oligodendrocyte apoptotic process [IDA]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of renal albumin absorption [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- peptidyl-serine phosphorylation [IDA]
- phagocytosis [IDA]
- platelet activation [TAS]
- platelet aggregation [TAS]
- platelet degranulation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of TOR signaling [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of dendritic cell chemotaxis [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of natural killer cell differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of phagocytosis [IDA]
- positive regulation of protein export from nucleus [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [IDA, ISS]
- positive regulation of protein tyrosine kinase activity [IDA]
- post-translational protein modification [TAS]
- protein kinase B signaling [IDA]
- protein phosphorylation [IDA]
- protein targeting to plasma membrane [IDA]
- proteolysis [TAS]
- receptor-mediated virion attachment to host cell [IDA]
- signal transduction [IDA, TAS]
- viral entry into host cell [IDA]
- viral genome replication [IDA]
Gene Ontology Molecular Function- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.999997121 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.999997121, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RTBDN GAS6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2221766 | |
| RTBDN GAS6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3077342 |
Curated By
- BioGRID