SRPRB
Gene Ontology Biological Process
Gene Ontology Cellular Component
HMOX1
Gene Ontology Biological Process
- angiogenesis [TAS]
- cell death [ISS]
- cellular iron ion homeostasis [TAS]
- cellular response to hypoxia [IEP]
- endothelial cell proliferation [TAS]
- erythrocyte homeostasis [IMP]
- excretion [IC]
- heme catabolic process [IDA, TAS]
- heme oxidation [IDA]
- intracellular signal transduction [TAS]
- iron ion homeostasis [IDA, IMP]
- low-density lipoprotein particle clearance [TAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of leukocyte migration [TAS]
- negative regulation of smooth muscle cell proliferation [IDA]
- porphyrin-containing compound metabolic process [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of chemokine biosynthetic process [TAS]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of vasodilation [IC]
- protein homooligomerization [IDA]
- regulation of angiogenesis [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [ISS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISS]
- response to hydrogen peroxide [ISS]
- response to nicotine [IDA]
- response to oxidative stress [IMP]
- small molecule metabolic process [TAS]
- smooth muscle hyperplasia [TAS]
- transmembrane transport [TAS]
- wound healing involved in inflammatory response [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.997179271 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.997179271, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRPRB HMOX1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9902 | BioGRID | 2241088 | |
| SRPRB HMOX1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9948 | BioGRID | 3120129 |
Curated By
- BioGRID