CER1
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- anterior/posterior axis specification [ISS]
- anterior/posterior pattern specification [ISS]
- bone mineralization [IMP]
- cell migration involved in gastrulation [ISS]
- cellular response to BMP stimulus [ISS]
- determination of dorsal identity [IMP]
- gastrulation [ISS]
- growth plate cartilage chondrocyte proliferation [ISS]
- negative regulation of BMP signaling pathway [ISS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of activin receptor signaling pathway [IDA, ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of mesoderm development [IMP, ISS]
- nervous system development [IMP]
- sequestering of BMP in extracellular matrix [IDA, ISS]
- signal transduction involved in regulation of gene expression [ISS]
- ureteric bud development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CAMK1
Gene Ontology Biological Process
- positive regulation of dendritic spine development [IMP]
- positive regulation of muscle cell differentiation [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of synapse structural plasticity [IMP]
- protein phosphorylation [IDA]
- regulation of muscle cell differentiation [IDA]
- regulation of protein binding [IDA]
- regulation of protein localization [IDA]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.862400376 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.862400376, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CER1 CAMK1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9055 | BioGRID | 3073029 |
Curated By
- BioGRID