HLA-DRB3
Gene Ontology Biological Process
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- T-helper 1 type immune response [IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cytokine-mediated signaling pathway [TAS]
- detection of bacterium [IMP]
- humoral immune response mediated by circulating immunoglobulin [IDA]
- immune response [IDA, IMP, TAS]
- immunoglobulin production involved in immunoglobulin mediated immune response [IDA]
- inflammatory response to antigenic stimulus [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of T cell proliferation [IMP]
- negative regulation of interferon-gamma production [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- protein tetramerization [IDA]
- regulation of interleukin-10 secretion [IDA]
- regulation of interleukin-4 production [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- MHC class II protein complex [ISS]
- clathrin-coated endocytic vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- external side of plasma membrane [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of plasma membrane [NAS]
- late endosome membrane [IDA]
- lysosomal membrane [IDA, TAS]
- membrane [IDA, TAS]
- plasma membrane [TAS]
- trans-Golgi network membrane [TAS]
- transport vesicle membrane [TAS]
SEMA4F
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.811125252 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.811125252, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HLA-DRB3 SEMA4F | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.825 | BioGRID | 3238047 |
Curated By
- BioGRID