SFRP2
Gene Ontology Biological Process
- cardiac left ventricle morphogenesis [IMP]
- cell-cell signaling [ISS]
- hematopoietic stem cell proliferation [ISS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of dermatome development [ISS]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [IDA]
- negative regulation of gene expression [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- non-canonical Wnt signaling pathway [IBA]
- outflow tract morphogenesis [IMP]
- patterning of blood vessels [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cell adhesion mediated by integrin [ISS]
- positive regulation of cell growth [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of fat cell differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of stem cell division [ISS]
- sclerotome development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MKLN1
Gene Ontology Biological Process
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.984638341 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.984638341, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SFRP2 MKLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9562 | BioGRID | 2250663 | |
| SFRP2 MKLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9206 | BioGRID | 3086008 |
Curated By
- BioGRID