BAIT
NRG1
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
neuregulin 1
GO Process (33)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- activation of transmembrane receptor protein tyrosine kinase activity [IDA, NAS]
- cardiac muscle cell differentiation [ISS]
- cardiac muscle cell myoblast differentiation [IDA]
- cell communication [TAS]
- cell proliferation [IDA]
- cellular protein complex disassembly [IGI]
- endocardial cell differentiation [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- mammary gland development [TAS]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of secretion [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neural crest cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of striated muscle cell differentiation [ISS]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein homodimerization activity [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- ventricular cardiac muscle cell differentiation [IDA]
- ventricular trabecula myocardium morphogenesis [IDA]
- wound healing [IDA, TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC38A10
PP1744
solute carrier family 38, member 10
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Cell Jul. 16, 2015; 162(2);425-40 [Pubmed: 26186194]
Quantitative Score
- 0.945571195 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.945571195, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Curated By
- BioGRID