LGALS8
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SORL1
Gene Ontology Biological Process
- negative regulation of MAP kinase activity [ISS]
- negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [IDA, IMP]
- negative regulation of beta-amyloid formation [IDA, IMP]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [IMP]
- negative regulation of neurofibrillary tangle assembly [ISS]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron death [ISS]
- negative regulation of protein binding [IDA]
- negative regulation of protein oligomerization [IMP]
- negative regulation of tau-protein kinase activity [ISS]
- positive regulation of ER to Golgi vesicle-mediated transport [IMP]
- positive regulation of choline O-acetyltransferase activity [ISS]
- positive regulation of early endosome to recycling endosome transport [IMP]
- positive regulation of endocytic recycling [IMP]
- positive regulation of protein catabolic process [IDA]
- positive regulation of protein exit from endoplasmic reticulum [IMP]
- positive regulation of protein localization to early endosome [IMP]
- post-Golgi vesicle-mediated transport [IDA]
- protein maturation [IDA]
- protein retention in Golgi apparatus [IDA]
- protein targeting [IDA, IMP]
- protein targeting to Golgi [IDA]
- protein targeting to lysosome [IDA]
- receptor-mediated endocytosis [TAS]
- regulation of smooth muscle cell migration [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi cisterna [IDA]
- early endosome [IDA, IMP]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- membrane [IDA]
- nuclear envelope lumen [IDA]
- recycling endosome [IMP]
- trans-Golgi network [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.996292759 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.996292759, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
LGALS8 SORL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9916 | BioGRID | 2240379 | |
LGALS8 SORL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9754 | BioGRID | 3079851 |
Curated By
- BioGRID