BAIT
PRMT6
HRMT1L6
protein arginine methyltransferase 6
GO Process (6)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- histone binding [IDA]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H2A-R3 specific) [IDA]
- histone methyltransferase activity (H3-R2 specific) [IDA]
- histone methyltransferase activity (H4-R3 specific) [IDA]
- protein binding [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
- histone binding [IDA]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H2A-R3 specific) [IDA]
- histone methyltransferase activity (H3-R2 specific) [IDA]
- histone methyltransferase activity (H4-R3 specific) [IDA]
- protein binding [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
Homo sapiens
PREY
ATP1A3
AHC2, CAPOS, DYT12, RDP
ATPase, Na+/K+ transporting, alpha 3 polypeptide
GO Process (9)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular potassium ion homeostasis [IDA]
- cellular response to steroid hormone stimulus [NAS]
- cellular sodium ion homeostasis [IDA]
- ion transmembrane transport [TAS]
- potassium ion import [IDA]
- response to glycoside [NAS]
- sodium ion export from cell [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Cell Jul. 16, 2015; 162(2);425-40 [Pubmed: 26186194]
Quantitative Score
- 0.866277221 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.866277221, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Curated By
- BioGRID