TNFSF11
Gene Ontology Biological Process
- TNFSF11-mediated signaling pathway [IDA]
- cytokine-mediated signaling pathway [IDA]
- immune response [NAS]
- monocyte chemotaxis [IDA]
- osteoclast differentiation [IDA, ISS, NAS]
- positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell activation [IDA]
- positive regulation of bone resorption [IDA]
- positive regulation of corticotropin-releasing hormone secretion [ISS]
- positive regulation of fever generation by positive regulation of prostaglandin secretion [ISS]
- positive regulation of homotypic cell-cell adhesion [IDA]
- positive regulation of intracellular signal transduction [IDA]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- tumor necrosis factor-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GOSR1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.999997717 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.999997717, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TNFSF11 GOSR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2220230 | |
TNFSF11 GOSR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3046092 |
Curated By
- BioGRID