ADAMTS12
Gene Ontology Biological Process
- cell migration [IMP]
- cell-matrix adhesion [IMP]
- cellular response to BMP stimulus [IDA]
- cellular response to interleukin-1 [IMP]
- cellular response to tumor necrosis factor [IMP]
- negative regulation of cellular response to hepatocyte growth factor stimulus [IDA]
- negative regulation of cellular response to vascular endothelial growth factor stimulus [IDA]
- negative regulation of chondrocyte differentiation [IDA]
- negative regulation of hepatocyte growth factor receptor signaling pathway [IDA]
- proteoglycan catabolic process [IDA]
- proteolysis involved in cellular protein catabolic process [IDA, IMP]
- regulation of endothelial tube morphogenesis [IDA]
- regulation of inflammatory response [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FKBP9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.999993305 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.999993305, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ADAMTS12 FKBP9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9918 | BioGRID | 2240206 | |
| ADAMTS12 FKBP9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9945 | BioGRID | 3125085 |
Curated By
- BioGRID