BAIT
CWC15
AD002, C11orf5, Cwf15, HSPC148, ORF5, AD-002
CWC15 spliceosome-associated protein
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SIRT1
SIR2L1, RP11-57G10.3
sirtuin 1
GO Process (87)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- DNA repair [TAS]
- DNA replication [TAS]
- DNA synthesis involved in DNA repair [ISS]
- angiogenesis [IDA]
- cell aging [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to hypoxia [IMP]
- cellular response to ionizing radiation [ISS]
- cellular response to starvation [ISS]
- cellular response to tumor necrosis factor [IDA]
- cellular triglyceride homeostasis [ISS]
- cholesterol homeostasis [ISS]
- chromatin organization [IMP]
- chromatin silencing [TAS]
- chromatin silencing at rDNA [IDA]
- circadian regulation of gene expression [IMP, ISS]
- establishment of chromatin silencing [IDA]
- fatty acid homeostasis [ISS]
- histone H3 deacetylation [IDA, IMP]
- histone H3-K9 modification [ISS]
- histone deacetylation [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- maintenance of chromatin silencing [IMP]
- methylation-dependent chromatin silencing [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of androgen receptor signaling pathway [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cAMP-dependent protein kinase activity [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of cellular response to testosterone stimulus [IMP]
- negative regulation of cellular senescence [IDA]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of helicase activity [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of peptidyl-lysine acetylation [IDA]
- negative regulation of phosphorylation [IMP]
- negative regulation of prostaglandin biosynthetic process [ISS]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISS]
- peptidyl-lysine acetylation [IMP]
- peptidyl-lysine deacetylation [IDA]
- positive regulation of DNA repair [IMP]
- positive regulation of MHC class II biosynthetic process [IDA]
- positive regulation of adaptive immune response [IDA]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of cAMP-dependent protein kinase activity [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular senescence [IDA]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of chromatin silencing [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of histone H3-K9 methylation [IMP]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of macroautophagy [IDA]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ADP-ribosylation [TAS]
- protein deacetylation [IDA, IMP]
- protein destabilization [ISS]
- protein ubiquitination [IDA]
- pyrimidine dimer repair by nucleotide-excision repair [IMP]
- regulation of bile acid biosynthetic process [ISS]
- regulation of cell proliferation [IMP]
- regulation of endodeoxyribonuclease activity [IMP]
- regulation of glucose metabolic process [ISS]
- regulation of mitotic cell cycle [IDA]
- regulation of peroxisome proliferator activated receptor signaling pathway [ISS]
- regulation of protein import into nucleus, translocation [IMP]
- regulation of smooth muscle cell apoptotic process [ISS]
- response to endoplasmic reticulum stress [ISS]
- response to hydrogen peroxide [IDA]
- response to insulin [ISS]
- response to oxidative stress [IDA]
- single strand break repair [IMP]
- triglyceride mobilization [ISS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function- HLH domain binding [IPI]
- NAD+ ADP-ribosyltransferase activity [TAS]
- NAD-dependent histone deacetylase activity [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [ISS]
- NAD-dependent protein deacetylase activity [IDA, IMP]
- bHLH transcription factor binding [IPI]
- deacetylase activity [IDA]
- enzyme binding [IPI]
- histone binding [IPI]
- histone deacetylase activity [IDA]
- identical protein binding [IPI]
- keratin filament binding [IPI]
- mitogen-activated protein kinase binding [IPI]
- p53 binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein deacetylase activity [IDA]
- transcription corepressor activity [IDA, ISS]
- transcription factor binding [IPI]
- HLH domain binding [IPI]
- NAD+ ADP-ribosyltransferase activity [TAS]
- NAD-dependent histone deacetylase activity [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [ISS]
- NAD-dependent protein deacetylase activity [IDA, IMP]
- bHLH transcription factor binding [IPI]
- deacetylase activity [IDA]
- enzyme binding [IPI]
- histone binding [IPI]
- histone deacetylase activity [IDA]
- identical protein binding [IPI]
- keratin filament binding [IPI]
- mitogen-activated protein kinase binding [IPI]
- p53 binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein deacetylase activity [IDA]
- transcription corepressor activity [IDA, ISS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- ESC/E(Z) complex [IDA]
- PML body [IDA]
- chromatin silencing complex [IDA]
- cytoplasm [IDA]
- mitochondrion [IDA]
- nuclear chromatin [IDA]
- nuclear envelope [IDA]
- nuclear euchromatin [IDA]
- nuclear heterochromatin [IDA]
- nuclear inner membrane [IDA]
- nucleolus [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- rDNA heterochromatin [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Cell Jul. 16, 2015; 162(2);425-40 [Pubmed: 26186194]
Quantitative Score
- 0.954033118 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.954033118, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CWC15 SIRT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9598 | BioGRID | 2249916 | |
| CWC15 SIRT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9431 | BioGRID | 3096148 |
Curated By
- BioGRID