DNAJB2
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of cell growth [IGI]
- negative regulation of cell proliferation [IGI]
- negative regulation of inclusion body assembly [IDA]
- negative regulation of protein deubiquitination [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [TAS]
- protein refolding [IDA]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP7A
Gene Ontology Biological Process
- T-helper cell differentiation [ISS]
- blood vessel development [ISS]
- blood vessel remodeling [ISS]
- cartilage development [ISS]
- catecholamine metabolic process [ISS]
- cellular copper ion homeostasis [IMP]
- central nervous system neuron development [ISS]
- cerebellar Purkinje cell differentiation [ISS]
- collagen fibril organization [ISS]
- copper ion export [ISS]
- copper ion import [ISS]
- copper ion transport [IMP]
- detoxification of copper ion [ISS]
- dopamine metabolic process [ISS]
- elastic fiber assembly [ISS]
- elastin biosynthetic process [ISS]
- epinephrine metabolic process [ISS]
- extracellular matrix organization [ISS]
- hair follicle morphogenesis [ISS]
- ion transmembrane transport [TAS]
- locomotory behavior [ISS]
- lung alveolus development [ISS]
- mitochondrion organization [ISS]
- negative regulation of metalloenzyme activity [ISS]
- neuron projection morphogenesis [ISS]
- norepinephrine metabolic process [ISS]
- peptidyl-lysine modification [ISS]
- pigmentation [ISS]
- positive regulation of catalytic activity [ISS]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of oxidoreductase activity [IDA]
- pyramidal neuron development [ISS]
- regulation of oxidative phosphorylation [ISS]
- removal of superoxide radicals [ISS]
- serotonin metabolic process [ISS]
- skin development [ISS]
- transmembrane transport [TAS]
- tryptophan metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.992359096 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.992359096, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DNAJB2 ATP7A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.944 | BioGRID | 3130931 |
Curated By
- BioGRID