BAIT
CCR1
CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1
chemokine (C-C motif) receptor 1
GO Process (21)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- calcium ion transport [IDA]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [TAS]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- chemokine-mediated signaling pathway [IDA]
- chemotaxis [NAS]
- cytokine-mediated signaling pathway [NAS]
- dendritic cell chemotaxis [TAS]
- exocytosis [IDA]
- immune response [IDA]
- metabolic process [IDA]
- negative regulation of bone mineralization [IMP]
- negative regulation of gene expression [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of osteoclast differentiation [IMP]
- response to wounding [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAQ
CMC1, G-ALPHA-q, GAQ, SWS, RP11-494N1.1
guanine nucleotide binding protein (G protein), q polypeptide
GO Process (11)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- action potential [IBA]
- activation of phospholipase C activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- glutamate receptor signaling pathway [IBA]
- negative regulation of protein kinase activity [IMP]
- phospholipase C-activating dopamine receptor signaling pathway [IBA]
- platelet activation [TAS]
- positive regulation of GTPase activity [IDA]
- protein stabilization [IMP]
- regulation of catenin import into nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Cell Jul. 16, 2015; 162(2);425-40 [Pubmed: 26186194]
Quantitative Score
- 0.982391269 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.982391269, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Curated By
- BioGRID