BAIT
FLOT2
ECS-1, ECS1, ESA, ESA1, M17S1
flotillin 2
GO Process (5)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC26A6
solute carrier family 26 (anion exchanger), member 6
GO Process (25)
GO Function (11)
GO Component (9)
Gene Ontology Biological Process
- angiotensin-activated signaling pathway [IDA]
- anion transport [IDA]
- bicarbonate transport [IDA, IMP]
- cellular response to cAMP [ISS]
- cellular response to fructose stimulus [ISS]
- cellular response to interferon-gamma [IDA]
- chloride transmembrane transport [IDA, IMP, ISS]
- chloride transport [IDA, IMP]
- epithelial fluid transport [ISS]
- formate transport [ISS]
- intestinal absorption [ISS]
- intracellular pH elevation [ISS]
- ion transport [TAS]
- mannitol transport [ISS]
- oxalate transport [IMP, ISS]
- oxalic acid secretion [ISS]
- positive regulation of dipeptide transmembrane transport [ISS]
- protein kinase C signaling [IDA]
- regulation of intracellular pH [IDA, IMP]
- sperm capacitation [ISS]
- sulfate transmembrane transport [IDA, IMP]
- sulfate transport [IMP, ISS]
- transepithelial chloride transport [IMP, ISS]
- transepithelial transport [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- PDZ domain binding [ISS]
- anion:anion antiporter activity [IDA, IMP, ISS]
- bicarbonate transmembrane transporter activity [IDA, IMP, ISS]
- chloride transmembrane transporter activity [IDA, IMP, ISS]
- efflux transmembrane transporter activity [ISS]
- formate efflux transmembrane transporter activity [ISS]
- formate transmembrane transporter activity [ISS]
- formate uptake transmembrane transporter activity [ISS]
- oxalate transmembrane transporter activity [IMP]
- protein binding [IPI]
- sulfate transmembrane transporter activity [IDA, IMP]
- PDZ domain binding [ISS]
- anion:anion antiporter activity [IDA, IMP, ISS]
- bicarbonate transmembrane transporter activity [IDA, IMP, ISS]
- chloride transmembrane transporter activity [IDA, IMP, ISS]
- efflux transmembrane transporter activity [ISS]
- formate efflux transmembrane transporter activity [ISS]
- formate transmembrane transporter activity [ISS]
- formate uptake transmembrane transporter activity [ISS]
- oxalate transmembrane transporter activity [IMP]
- protein binding [IPI]
- sulfate transmembrane transporter activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Cell Jul. 16, 2015; 162(2);425-40 [Pubmed: 26186194]
Quantitative Score
- 0.848873721 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.848873721, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Curated By
- BioGRID